The disease was described in the 5th century bce by hippocrates, and epidemics were described in the 6th century ad by aetius. The bacilli are beaded due to the metachromatic volutin granules. Twentyfive cases of nontoxigenic corynebacterium diphtheriae infection were recorded in poland during 20042012, of which 18 were invasive. Diphtheria is an acute infectious disease that is caused by toxinproducing strains of corynebacterium diphtheriae, a grampositve rod 1. A weakly toxigeniccorynebacterium diphtheriae strain was isolated from the bone aspirate. Itis taxonomy is based on the latest scientific consensus available, and is provided as a general reference source for interested parties. Download corynebacterium types of bacteria corynebacterium diphtheriae corynebacterium ulcerans corynebacterium ppt for free. Discover everything scribd has to offer, including books and audiobooks from major publishers. After infection by direct contact, sneezing or coughing. Ppt corynebacterium diphtheriae powerpoint presentation. Corynebacterium diphtheriae is the bacterium that causes the disease diphtheria. More than half of these are connected to human and animal infections, with the most prominent member of the pathogenic species being corynebacterium diphtheriae, which is also the type species of the genus. Hosted by the usgs core science analytics and synthesis.
Most strains require nicotinic and pantothenic acids for growth. Novel diphtheriae in domestic cats centers for disease. In this article we will discuss about corynebacterium diphtheriae which causes a disease called diptheria in humans. However, if there are large numbers of pathogenic organisms within the inspired air or if the host defenses are. Emad abdelhameed morad lecturer of medical microbiology and immunology. Ppt corynebacterium diphtheriae powerpoint presentation free to download id.
Diphtheria is a serious bacterial infection that affects the mucous membranes of the throat and nose. Learn vocabulary, terms, and more with flashcards, games, and other study tools. The toxin inhibits cellular protein synthesis and is responsible for local tissue destruction and pseudomembrane formation 14. Pronunciation of corynebacterium diphtheriae with 2 audio pronunciations, 3 synonyms, 2 meanings, 2 translations and more for corynebacterium diphtheriae. Some corynebacteria are part of the normal flora of humans, finding a suitable niche in virtually every anatomic site, especially the skin and nares. Alcoholism, homelessness, hepatic cirrhosis, and dental caries were predisposing factors for infection. While every effort has been made to provide the most reliable and uptodate information available, ultimate legal requirements with respect to species are contained in. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. They are bacilli rodshaped, and in some phases of life they are, more particularly, clubshaped, which inspired the genus name coryneform means clubshaped. Corynebacterium diphtheriae an overview sciencedirect. Page designed through the cooperative efforts of interagency itis teams. If there is clinical suspicion of diphtheria microbiological laboratory must be informed immediately in order to use in the cultural approach appropriate media. Corynebacterium diphtheriae study guide by knpearso includes 12 questions covering vocabulary, terms and more.
Two other zoonotic corynebacterial species, corynebacterium ulcerans and corynebacterium pseudotuberculosis, can also produce diphtheria toxin. Diphtheria was a serious contagious disease throughout much of. Corynebacterium introduction the genus corynebacterium consists of a diverse group of bacteria including. Diphtheria is caused by both toxigenic corynebacterium diphtheriae and corynebacterium ulcerans strains harboring lysogenic betacorynephages bearing the tox gene. However, for 17% of cases, no concomitant diseases or predisposing factors were found. Corynebacteria are grampositive, catalase positive, nonsporeforming, nonmotile, rodshaped bacteria that are straight or slightly curved, with clubbed ends from the greek koryne, club. Corynebacterium diphtheriae is the leading causing agent of diphtheria. Diphtheria was a serious contagious disease throughout much of the world until. Biotype mitis and gravis produce larger, convex colonies with weak betahemolysis. Corynebacterium diphtheriae is an aerobic grampositive bacterium which secretes a toxin that inactivates human elongation factor eef2, thus inhibiting translation during protein synthesis by human cells. Taxonomy navigation corynebacterium all lower taxonomy nodes 25 common name isynonym iother names i bacillus diphtheriae kruse in flugge 1886 bacterium diphtheriae kruse 1886 migula 1900 microsporon diphthericum sic klebs 1875 microsporon. Ppt corynebacterium spp and related organisms powerpoint. Diphtheria communicable disease management protocol diphtheria august 2016 1 this protocol applies to the management of toxinproducing strains of corynebacterium diphtheriae, ulcerans or pseudotuberculosis only.
Diphtheria 107 7 diphtheria is an acute, toxinmediated disease caused by the bacterium. Novel nontoxigenic corynebacterium diphtheriae was isolated from a domestic cat with severe otitis. Corynebacterium diphtheriae definition of corynebacterium. If so, share your ppt presentation slides online with. Corynebacterium diphtheriae an overview sciencedirect topics. Formam grandes colonias quando cultivadas em meio agar sangue durante uma noite. View corynebacterium ppts online, safely and virusfree. Winner of the standing ovation award for best powerpoint templates from presentations magazine. Suitable for investigation throat swabs with removal under the false membranes, and nose or wound swabs, tissue if necessary. Nontoxigenic highly pathogenic clone of corynebacterium. Global population of corynebacterium diphtheriae is mainly represented by local genotypes whose circulation is under strong influence of human host factors, including health control measures, first of all, vaccination, and social economic conditions. Corynebacterium diphtheriae the causative agent of diphtheria, which produces a potent exotoxin reservoir humans epidemiology airborne, infected fomites, infected skin. The name of the disease is derived from the greek diphthera, meaning leather hide. Although it spreads easily from one person to another, diphtheria can be prevented through the.
Corynebacterium diphtheriae is a causative agent of diphtheria. It is a facultatively anaerobic, gram positive organism characterized by nonencapsulated, nonsporulated, immobile, straight or curved rods. Crystal structure of nucleotidefree diphtheria toxin. In situ lysogenic conversion of nontoxigenic strains to a toxigenic phenotype. The complete genome sequence and analysis of corynebacterium. Corynebacterium species are characterized by a complex cell wall architecture. The bacterium that causes diphtheria was first described by klebs in 1883, and was cultivated by loeffler in 1884, who applied kochs postulates and properly identified corynebacterium diphtheriae as the agent of the disease.
Corynebacterium diphtheriae colonies on blood agar. The presentation is indolent and nonprogressive and is only rarely associated with signs of. Corynebacterium diphtheriae disease general microscience. Diphtheria is caused by toxinproducing strains of the bacterium corynebacterium diphtheriae 6. Three strains of corynebacterium diphtheriae are recognized, gravis, intermedius and mitis. They are listed here by falling order of the severity of the disease that they produce in humans. The toxin produced at the site of the membrane is absorbed into the bloodstream and then distributed to the. It is a gram positive, nonmotile, non spore forming bacteria. Quizlet flashcards, activities and games help you improve your grades. Corynebacterium diphtheriae is classified into biotypes mitis, intermedius, and gravis according to colony morphology, as well as into lysotypes based upon corynebacteriophage sensitivity. Rapid detection and molecular differentiation of toxigenic. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. The disease occurs primarily in tropical regions and underdeveloped countries but has been known to appear throughout the world.
Corynebacterium diphtheriae wikipedia, a enciclopedia livre. Corynebacterium diphtheriae health sciences wellness. Corynebacterium diphtheriae is spread by droplets, secretions, or direct contact. The bacilli are swollen at one end club shaped bacilli.
The site of infection, generally the throat, becomes sore and swollen. Other articles where corynebacterium diphtheriae is discussed. In the past, it was mainly through such healthy carriers that the disease was spread, and toxigenic bacteria were maintained in the population. The bacterium that causes diphtheria was first described by klebs in 1883, and was cultivated by loeffler in 1884, who applied kochs postulates and properly identified corynebacterium diphtheriae as. Before mass immunization of children, carrier rates of c.
Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. It is a nonmotile, nonencapsulated, nonsporulating grampositive rodshaped bacterium with a high gccontent and occurs in four biovars. Diphtheria manifests as either an upper respiratory tract or cutaneous infection and is caused by the aerobic grampositive bacteria, corynebacterium diphtheria. Characterization of corynebacterium species in macaques external icon. Diphtheria toxoid 3 doses 2,4,6 years booster dose after every 10 years. Toxigenic strains are lysogenic for one of a family of corynebacteriophages that carry the structural gene for diphtheria toxin, tox. Contact investigation and carrier study of human and animal contacts. Often, whole families died of the disease in a few weeks. Toxigenic strains in susceptible individuals can cause disease by multiplying and secreting diphtheria toxin into either skin or nasopharyngeal. It is upper respiratory tract illness and it is a contageous disease 1. Corynebacterium diphtheria produce very potent toxin when infected with a.
Corynebacterium diphtheriae is classified into biotypes mitis, intermedius, and gravis. The characteristic clinical presentation is the presence of a grayishwhite, fibrinous and firmly adherent pseudomembrane figure 2 that forms within the first few. Antitoxin neutralizes the unbound toxin in the blood. Corynebacterium classification corynebacterium diphtheria and diphtheroids look like c. It is upper respiratory tract illness and it is a contageous disease. Corynebacterium diphtheriae diphtheria infectious disease and. Remove this presentation flag as inappropriate i dont like this i like this remember as a favorite. Multilocus sequence typing identifies evidence for recombination and two distinct lineages of corynebacterium diphtheriae external icon. The results of the treatment were rapidly satisfactory, after surgical drainage and antibiotic therapy with pristinamycin. A free powerpoint ppt presentation displayed as a flash slide show on id. Corynebacterium diphtheriae diphtheria infectious disease. Corynebacteria are pleomorphic rods that occur in angular arrangements. Introduction corynebacteria coryneform bacteria a group of nonspore forming, gram positive bacilli, tend to be clubbed or irregularly shaped. Morphology gram positive bacilli arranged in acute angled pairs chineese letter arrangement.
Septic osteomyelitis of the hip in a previously healthy child is described. Corynebacterium diphtheriae respiratory tract infections although inhaled air contains many particles, including microorganisms, the host defense mechanisms in the respiratory tract frequently prevent infection. Although diphtheria disease is rare in the united states, it appears that corynebacterium diphtheriae continues to circulate in areas of the country with previously endemic diphtheria. Corynebacterium diphtheriae is a nonmotile, noncapsulated, clubshaped, grampositive bacillus. Corynebacterium diphtheriae nkyomniventures xpowerpoint. C diphtheria is responsible for both endemic and epidemic diseases, and it was first described in the 5th century bc by hippocrates. Displaying powerpoint presentation on corynebacterium types of bacteria corynebacterium diphtheriae corynebacterium ulcerans corynebacterium available to view or download. Gram positive bacilli arranged in acute angled pairs chineese letter arrangement.
Corynebacterium diphtheriae on columbia agar with 5% defibrinated sheep blood. Corynebacterium diphtheriae medical microbiology ncbi. Diphtheria is an infection caused by the bacterium corynebacterium diphtheriae. Diphtheria is caused by both toxigenic corynebacterium diphtheriae and corynebacterium ulcerans strains harboring lysogenic betacorynephages bearing the tox x encodes the diphtheria toxin dt, which is responsible for the systemic symptoms of diphtheria. Local manifestation depend on the site of faucial lesion.
Corynebacterium diphtheriae medical microbiology ncbi bookshelf. Immunology and vaccinepreventable diseases pink book. Some are saprophytic some produce disease in animals. Corynebacterium diphtheriae is a pathogenic bacterium that causes diphtheria. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect. Diphtheria causes a thick covering in the back of the throat. All strains produce the identical toxin and are capable of colonizing the throat. Corynebacterium spp and related organisms is the property of its rightful owner.