Corynebacterium diphtheriae medical microbiology ncbi. Corynebacterium diphtheriae is a rodshaped, gram positive, non sporeforming, and nonmotile bacterium. Some are saprophytic some produce disease in animals. It is upper respiratory tract illness and it is a contageous disease. Introduction corynebacteria coryneform bacteria a group of nonspore forming, gram positive bacilli, tend to be clubbed or irregularly shaped. Morphology gram positive bacilli arranged in acute angled pairs chineese letter arrangement. All strains produce the identical toxin and are capable of colonizing the throat. The presentation is indolent and nonprogressive and is only rarely associated with signs of. Corynebacterium diphtheriae is an aerobic grampositive bacterium which secretes a toxin that inactivates human elongation factor eef2, thus inhibiting translation during protein synthesis by human cells. Contact investigation and carrier study of human and animal contacts. Corynebacterium species are characterized by a complex cell wall architecture. Diphtheria is caused by both toxigenic corynebacterium diphtheriae and corynebacterium ulcerans strains harboring lysogenic betacorynephages bearing the tox x encodes the diphtheria toxin dt, which is responsible for the systemic symptoms of diphtheria.
Corynebacterium classification corynebacterium diphtheria and diphtheroids look like c. To date the genus corynebacterium comprises 88 species. Corynebacterium diphtheriae nkyomniventures xpowerpoint. They are listed here by falling order of the severity of the disease that they produce in humans. Alcoholism, homelessness, hepatic cirrhosis, and dental caries were predisposing factors for infection. Toxigenic strains in susceptible individuals can cause disease by multiplying and secreting diphtheria toxin into either skin or nasopharyngeal. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect. Novel nontoxigenic corynebacterium diphtheriae was isolated from a domestic cat with severe otitis.
Although it spreads easily from one person to another, diphtheria can be prevented through the. Diphtheria causes a thick covering in the back of the throat. Corynebacterium diphtheriae medical microbiology ncbi bookshelf. The bacterium that causes diphtheria was first described by klebs in 1883, and was cultivated by loeffler in 1884, who applied kochs postulates and properly identified corynebacterium diphtheriae as the agent of the disease. Download corynebacterium types of bacteria corynebacterium diphtheriae corynebacterium ulcerans corynebacterium ppt for free. The results of the treatment were rapidly satisfactory, after surgical drainage and antibiotic therapy with pristinamycin. Local manifestation depend on the site of faucial lesion.
Characterization of corynebacterium species in macaques external icon. However, it is not a legal authority for statutory or regulatory purposes. Diphtheria toxoid 3 doses 2,4,6 years booster dose after every 10 years. Formam grandes colonias quando cultivadas em meio agar sangue durante uma noite. The complete genome sequence and analysis of corynebacterium. Immunology and vaccinepreventable diseases pink book.
Corynebacterium diphtheriae respiratory tract infections although inhaled air contains many particles, including microorganisms, the host defense mechanisms in the respiratory tract frequently prevent infection. Corynebacterium spp and related organisms is the property of its rightful owner. Nontoxigenic highly pathogenic clone of corynebacterium. Corynebacterium diphtheriae is the leading causing agent of diphtheria. Multilocus sequence typing identifies evidence for recombination and two distinct lineages of corynebacterium diphtheriae external icon. Quizlet flashcards, activities and games help you improve your grades. Displaying powerpoint presentation on corynebacterium types of bacteria corynebacterium diphtheriae corynebacterium ulcerans corynebacterium available to view or download. Diphtheria was a serious contagious disease throughout much of. Ppt corynebacterium diphtheriae powerpoint presentation free to download id. The toxin produced at the site of the membrane is absorbed into the bloodstream and then distributed to the.
The bacterium that causes diphtheria was first described by klebs in 1883, and was cultivated by loeffler in 1884, who applied kochs postulates and properly identified corynebacterium diphtheriae as. Corynebacterium diphtheriae diphtheria infectious disease. Before mass immunization of children, carrier rates of c. Ppt corynebacterium diphtheriae powerpoint presentation. The disease occurs primarily in tropical regions and underdeveloped countries but has been known to appear throughout the world.
The characteristic clinical presentation is the presence of a grayishwhite, fibrinous and firmly adherent pseudomembrane figure 2 that forms within the first few. Corynebacterium diphtheria produce very potent toxin when infected with a. Corynebacterium diphtheriae an overview sciencedirect. Diphtheria is an infection caused by the bacterium corynebacterium diphtheriae.
After infection by direct contact, sneezing or coughing. A free powerpoint ppt presentation displayed as a flash slide show on id. Corynebacteria are grampositive, catalase positive, nonsporeforming, nonmotile, rodshaped bacteria that are straight or slightly curved, with clubbed ends from the greek koryne, club. Gram positive bacilli arranged in acute angled pairs chineese letter arrangement.
The bacilli are swollen at one end club shaped bacilli. Corynebacteria are pleomorphic rods that occur in angular arrangements. While every effort has been made to provide the most reliable and uptodate information available, ultimate legal requirements with respect to species are contained in. Corynebacterium diphtheriae an overview sciencedirect topics. Diphtheria communicable disease management protocol diphtheria august 2016 1 this protocol applies to the management of toxinproducing strains of corynebacterium diphtheriae, ulcerans or pseudotuberculosis only. Corynebacterium diphtheriae is a pathogenic bacterium that causes diphtheria. Remove this presentation flag as inappropriate i dont like this i like this remember as a favorite. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Often, whole families died of the disease in a few weeks. Three strains of corynebacterium diphtheriae are recognized, gravis, intermedius and mitis. A weakly toxigeniccorynebacterium diphtheriae strain was isolated from the bone aspirate.
Diphtheria is caused by toxinproducing strains of the bacterium corynebacterium diphtheriae 6. Rapid detection and molecular differentiation of toxigenic. Itis taxonomy is based on the latest scientific consensus available, and is provided as a general reference source for interested parties. Some corynebacteria are part of the normal flora of humans, finding a suitable niche in virtually every anatomic site, especially the skin and nares. Antitoxin neutralizes the unbound toxin in the blood. Corynebacterium diphtheriae is a nonmotile, noncapsulated, clubshaped, grampositive bacillus. C diphtheria is responsible for both endemic and epidemic diseases, and it was first described in the 5th century bc by hippocrates. Diphtheria is an acute infectious disease that is caused by toxinproducing strains of corynebacterium diphtheriae, a grampositve rod 1.
It is a nonmotile, nonencapsulated, nonsporulating grampositive rodshaped bacterium with a high gccontent and occurs in four biovars. Corynebacterium diphtheriae diphtheria infectious disease and. Corynebacterium diphtheriae on columbia agar with 5% defibrinated sheep blood. Corynebacterium diphtheriae study guide by knpearso includes 12 questions covering vocabulary, terms and more. Corynebacterium diphtheriae is classified into biotypes mitis, intermedius, and gravis. Ppt corynebacterium spp and related organisms powerpoint. It is upper respiratory tract illness and it is a contageous disease 1. Novel diphtheriae in domestic cats centers for disease. It is a gram positive, nonmotile, non spore forming bacteria.
Biotype mitis and gravis produce larger, convex colonies with weak betahemolysis. Toxigenic strains are lysogenic for one of a family of corynebacteriophages that carry the structural gene for diphtheria toxin, tox. The name of the disease is derived from the greek diphthera, meaning leather hide. Septic osteomyelitis of the hip in a previously healthy child is described. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from.
In situ lysogenic conversion of nontoxigenic strains to a toxigenic phenotype. Global population of corynebacterium diphtheriae is mainly represented by local genotypes whose circulation is under strong influence of human host factors, including health control measures, first of all, vaccination, and social economic conditions. Although diphtheria disease is rare in the united states, it appears that corynebacterium diphtheriae continues to circulate in areas of the country with previously endemic diphtheria. Diphtheria manifests as either an upper respiratory tract or cutaneous infection and is caused by the aerobic grampositive bacteria, corynebacterium diphtheria. Corynebacterium diphtheriae is spread by droplets, secretions, or direct contact. More than half of these are connected to human and animal infections, with the most prominent member of the pathogenic species being corynebacterium diphtheriae, which is also the type species of the genus. Corynebacterium diphtheriae is classified into biotypes mitis, intermedius, and gravis according to colony morphology, as well as into lysotypes based upon corynebacteriophage sensitivity. Corynebacterium diphtheriae health sciences wellness. Diphtheria was a serious contagious disease throughout much of the world until.
If so, share your ppt presentation slides online with. View corynebacterium ppts online, safely and virusfree. Winner of the standing ovation award for best powerpoint templates from presentations magazine. In the past, it was mainly through such healthy carriers that the disease was spread, and toxigenic bacteria were maintained in the population. Corynebacterium diphtheriae disease general microscience.
They are bacilli rodshaped, and in some phases of life they are, more particularly, clubshaped, which inspired the genus name coryneform means clubshaped. Taxonomy navigation corynebacterium all lower taxonomy nodes 25 common name isynonym iother names i bacillus diphtheriae kruse in flugge 1886 bacterium diphtheriae kruse 1886 migula 1900 microsporon diphthericum sic klebs 1875 microsporon. Hosted by the usgs core science analytics and synthesis. Discover everything scribd has to offer, including books and audiobooks from major publishers. Crystal structure of nucleotidefree diphtheria toxin. Suitable for investigation throat swabs with removal under the false membranes, and nose or wound swabs, tissue if necessary. Page designed through the cooperative efforts of interagency itis teams. The bacilli are beaded due to the metachromatic volutin granules. Corynebacterium diphtheriae colonies on blood agar. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. Corynebacterium diphtheriae definition of corynebacterium.
Diphtheria is a serious bacterial infection that affects the mucous membranes of the throat and nose. Diphtheria 107 7 diphtheria is an acute, toxinmediated disease caused by the bacterium. If there is clinical suspicion of diphtheria microbiological laboratory must be informed immediately in order to use in the cultural approach appropriate media. However, if there are large numbers of pathogenic organisms within the inspired air or if the host defenses are. However, for 17% of cases, no concomitant diseases or predisposing factors were found. Corynebacterium diphtheriae the causative agent of diphtheria, which produces a potent exotoxin reservoir humans epidemiology airborne, infected fomites, infected skin.
Twentyfive cases of nontoxigenic corynebacterium diphtheriae infection were recorded in poland during 20042012, of which 18 were invasive. The toxin inhibits cellular protein synthesis and is responsible for local tissue destruction and pseudomembrane formation 14. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. Pronunciation of corynebacterium diphtheriae with 2 audio pronunciations, 3 synonyms, 2 meanings, 2 translations and more for corynebacterium diphtheriae. Emad abdelhameed morad lecturer of medical microbiology and immunology. Corynebacterium diphtheriae is the bacterium that causes the disease diphtheria.
Most strains require nicotinic and pantothenic acids for growth. Two other zoonotic corynebacterial species, corynebacterium ulcerans and corynebacterium pseudotuberculosis, can also produce diphtheria toxin. Diphtheria is caused by both toxigenic corynebacterium diphtheriae and corynebacterium ulcerans strains harboring lysogenic betacorynephages bearing the tox gene. It is a facultatively anaerobic, gram positive organism characterized by nonencapsulated, nonsporulated, immobile, straight or curved rods. Corynebacterium diphtheriae wikipedia, a enciclopedia livre. The site of infection, generally the throat, becomes sore and swollen. Corynebacterium introduction the genus corynebacterium consists of a diverse group of bacteria including. Other articles where corynebacterium diphtheriae is discussed. The disease was described in the 5th century bce by hippocrates, and epidemics were described in the 6th century ad by aetius.